|
KMID : 0861319980120010116
|
|
Korean Journal of Oriental Medical Pathology
1998 Volume.12 No. 1 p.116 ~ p.125
|
|
|
Effect of Gamdutang Water Extract on Cardiovascular Anaphylaxis
|
|
李柱憲/Lee, Joo-Heon
李基常/文炳淳/Lee, Key-Sang/Moon, Byung-Soon
|
|
|
Abstract
|
|
|
This study was investigated the inhibitory activity of Gamdutang water extract on type I immediate hypersensitivity of anaphylatic type.
The results of this study were as follows:
1. Gamdutang water extract ameliorated the cardiovascular anaphylactic response and thus reduced lethality in the vivo rat model (pithed rat).
2. The ameliorating effect was related to the blunting of sustained depressor effect appeared follwing antigen challenge, but the tachycardic response was not influenced.
3. In the isolated guinea pig heart, Gamdutang water extract did not prevent the occurrence of cardiac failure induced by anaphylaxis.
4. Gamdutang water extract did not relax the contractility response of isolated guinea pig trachea to LTD4, histamine or 5-HT. This result indicates that the Gamdutang water extract does not possess direct inhibitory action on these major anaphylactic mediators.
5. Gamdutang water extract could be effective against other types of anaphylaxis since the substance was effective in PCA test.
The results suggest that Gamdutang water extract is effective in preventing Type I allergy such as anaphylaxis. Gamdutang water extract may not antagonized directly major anaphylactic mediators such as LTD4, histamine or 5-HT. Rather it seems that Gamdutang water extract interferes the release of these mediators from mast cells in the advent of anaphylaxis, or it may inhibit the biosynthesis of these substances. Gamdutang water extracts main site of action seems to be peripheral resistance vessels, not the heart.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|